Related Jobs

Jobs Home » Browse Jobs » Senior Laboratory Research Scientist – Viral Vector service

Senior Laboratory Research Scientist – Viral Vector service

Company Details
Industry: Health care
Description: The Francis Crick Institute is a biomedical research centre in London, which was established in 2010 and opened in 2016. The institute is a partnership between Cancer Research UK, Imperial College London, King's College London, the Medical Research Council, University College London and the Wellcome Trust.
Job Description

The post holder will generate viral vectors to enable the research carried out at the Crick in fields ranging from cancer biology to systems neuroscience and consult Crick researchers on production and application of these vectors. Viral vectors generated by this service will be used in a range of applications, including for tracing of neuronal connectivity, recording and manipulation of neuronal activity in the mouse brain, generation of transgenic mouse lines using CRISPR-mediated gene editing, CRISPR screens aiming to understand mechanisms of development, oncogenesis, or gene regulation and so on. The post holder will closely work with Crick virologists and molecular biologists.

Key responsibilities:

The successful candidate will:

• Produce recombinant viral vectors, including adeno-associated virus (AAV), lentivirus, rabies virus, and Sindbis virus

• Develop and optimize viral packaging and purification protocols

• Develop and apply quality benchmarks to ensure high quality and titre of resulting virus preparations

• Generate and modify plasmids for viral production, including cloning of custom CRISPR libraries

• Carry out organizational tasks essential for operation of the facility, such as budget planning, biosafety risk assessments etc. Key experience and competencies The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following: Essential

• PhD or relevant experience in virology, molecular biology or a related field

• Experience in tissue culture work, ideally at containment level 2

• Experience with viral production, especially AAV, lentivirus, or rabies production

• Excellent work ethic and ability to work to deadlines

• Strong organizational and record-keeping skills Desirable

• Experience in molecular cloning

Employment Type: Contract Based
Contact Information
Name: Andreas Schaefer